Geopolitical dynamics in the post-pandemic era are experiencing significant changes, creating new challenges and opportunities for countries around the world. The COVID-19 pandemic has not only changed daily life, but also affected international relations, global security and the economy. Countries are now more aware of their dependence on each other, which has led to a shift in geopolitical power. First, tensions between major powers, such as the US and China, are increasing. Competition in technology, trade and military creates global uncertainty. China’s investment in infrastructure through the Belt and Road Initiative (BRI) is a strategic tool to increase its influence in Asia and Africa. Meanwhile, the US is seeking to build new alliances, such as the Quad with India, Japan and Australia, to balance China’s power in the Indo-Pacific. Second, the pandemic has accelerated the process of economic decentralization. Countries are starting to shift supply chains from heavy dependence on China to alternative locations, such as India and Vietnam. This phenomenon, known as reshoring or nearshoring, enables economic resilience and reduces vulnerability to global disruptions such as those experienced during the pandemic. Third, health issues now dominate the geopolitical agenda. Countries are competing to develop and distribute vaccines, leading to inequities in access. Developed countries often dominate vaccine supplies, while developing countries face difficulties. This creates new tensions, as well as worsening international relations and increasing discontent. Furthermore, climate change is increasingly becoming the main focus of diplomacy. Countries are starting to realize that these challenges are cross-border and require multilateral cooperation. The COP26 conference resulted in new commitments to reduce emissions, but implementation still depends on the active involvement of all countries. In the post-pandemic era, action on climate change could provide differentiation for global powers. Cybersecurity is also a major issue. Cyberattacks increased during and after the pandemic, forcing countries to upgrade security infrastructure. Countries such as Russia and China are accused of using cyber attacks as a tool to achieve their political and military goals. The establishment of international coordination in cyber security is very important to protect critical data and infrastructure. Finally, domestic politics also influences geopolitical dynamics. The rise of populism and nationalism in many countries poses new challenges in international relations. Nationalist leaders often face difficulty in achieving multilateral consensus, potentially hampering progress on global issues such as climate change and health. With all these developments, geopolitical dynamics in the post-pandemic era require serious attention from world leaders. Collaboration, innovation and adaptation will be the keys to facing new challenges that arise and taking advantage of existing opportunities. Dialogue and openness between countries in this era is very crucial to creating a more stable and prosperous world.